在这段视频当中，马克龙穿着深色高领毛衣，语速明显和其他视频的讲话速度相比要慢，精神头不足，表示自己和前一天确诊之际有着相同的症状：疲乏，头疼，干咳。但他表示自己依旧在工作，只不过速度有所下降，“仍然在处理优先级的重要档案”，并提到了新冠疫情危机和英国与欧盟的谈判等。他承诺，自己“每天都非常透明地了解自身病情的走势，没有理由恶化”。
马克龙自从本周四确诊感染新冠病毒之后，就在巴黎郊区的凡尔赛市的拉郎特尔内宅邸隔离，由总统府爱丽舍宫首席医生，前军队急诊医师让-克里斯托弗-皮罗雄诊治。第一夫人布丽吉特-马克龙检测结果呈阴性，在总统府爱丽舍宫隔离。
马克龙在视频当中还劝说民众，称自己虽然被重重保护起来，且他本人非常当心，却仍然中招，这“显示出，在这一病毒面前，真的无人可以说自己不会被感染”。他调侃道，自己感染病毒，“有可能是某个时刻的疏忽导致的，有可能是某个时刻不那么幸运，因而中招”。他以自身为例，呼吁所有法国人警惕起来。
The newness of the novel coronavirus coupled with the quick development of a vaccine has put Pfizer and BioNTech’s shots under the proverbial microscope — particularly about the ingredients it uses.
While there’s no question this happened at warp speed, experts agree the listed ingredients are pretty standard.
In fact, they’re “almost simpler and more straightforward than any other vaccine,” according to Kyle Anderson, an assistant professor of biochemistry, microbiology and immunology at the University of Saskatchewan.
“That’s because it’s a revolution in vaccine making,” he said. “There’s nothing in this vaccine that rings any alarm bells.”
Pfizer’s vaccine was approved by Health Canada on Dec. 9. Canadians across the country have rolled up their sleeves this week to be among the first to receive the shot, which touts a 95 per cent effectiveness rate and no serious side effects.
Its ingredients might look complicated, said Anderson, but they can be easily organized into four basic categories:
This is the only active ingredient in the vaccine.
The mRNA — messenger RNA technology — sends tiny snippets of genetic code to cells, telling them to build proteins. In this case, it triggers the immune system to produce protective antibodies without using actual bits of the virus. “Old-fashioned” types of vaccines, required scientists having to express it in cells or chicken eggs to get the proteins right, Anderson said.
“And then we had to do all this clean-up,” he said. “If we had problems with cleaning and purifying it, we could get adverse reactions or add things like mercury compounds to stabilize that. … These are completely avoided with these mRNA-based vaccines.”
The lipid molecule in Pfizer’s vaccine contains four components.
“Each is necessary for the mRNA — the medicinal ingredient — to gain entry into cells and be expressed,” said Roderick Slavcev, a professor at the University of Waterloo’s School of Pharmacy. Slavcev and a team are currently developing a DNA-based vaccine.
The molecule essentially protects the mRNA. Without it, the vital active ingredient could be broken down before getting that genetic code to the cell.
This connection of fat is particularly delicate, experts say, which is why the Pfizer vaccine requires a subzero temperature for storage.
The 0.05 mg of PEG in Pfizer’s vaccine is “such a small quantity,” Anderson said.
“It’s like the carrier of the message. It’s the envelope that your letter came in, and then you recycle the paper,” he continued.
“If you eat, say, a steak, you’re getting a lot of these fats and in far higher quantities, but they’re digested and you just don’t think about it.”
Lipids might also have a bad rap because “they have such long, complicated, really unpronounceable names,” he added.
“It kind of reads like a shampoo bottle,” he said with a laugh.
“All these Xs and Ys and Zs and numbers, it looks like an alien language. And it is to most of us. But it’s just essentially a fat droplet.”
Salts, like fats, are nothing new to vaccines, the experts agree. They’re there for two reasons — to balance and to stabilize.
Having salt components allows cells to retain their proper shape, Anderson said.
“If you get an IV at the hospital, there are salts and sugars in there. It makes your cells a little happier. They’re there to help balance it out,” he said.
The sugar-water mixture is there to protect and to stabilize the vaccine during freezing.
Pfizer’s vaccine needs to be stored at an ultracold -70 C. The sugar helps keep things stable under this temperature, the experts said.
It is, again, another common addition to a vaccine and other drug and pharmaceutical products.
“We’re more likely to not trust something that we haven’t seen or heard of before,” Anderson said.
“Sucrose, we know it’s sugar. But we don’t necessarily think about all these fats in our body that have these complicated names, and there are hundreds more with complicated names.”
Ultimately, there’s nothing in that ingredient list that is questionable or unnecessary, Slavcev said.
“Potentials for allergic responses or other adverse responses are always possible. It’s impossible to predict how every human will react,” he said, adding that all adverse reactions are and will continue to be documented.
As for the speed of the vaccine’s development? Get used to it.
“This is the future of vaccines,” Anderson said.
The government is planning to reallocate some of this year’s remaining stimulus funds to pay for mass vaccination in 2021.
By Dec. 14, the government had spent 70 percent – or Rp 481.6 trillion (US$34.12 billion) – of the nation’s Rp 695.2 trillion stimulus package in an effort to strengthen the healthcare system and tend to the economy as it reeled from the coronavirus outbreak.
“We think that it may not be possible to spend 100 percent of the budget this year,” Budi Gunadi Sadikin, the head of the economic recovery task force, told reporters during a virtual press conference on Wednesday. “We have already had discussions that the remaining funds will be used for the national vaccination program.”
President Joko “Jokowi” Widodo announced on Wednesday that the government would provide free vaccines to all Indonesians in 2021 and asked Cabinet members to prioritize the vaccination effort next year.
“I have instructed the finance minister to prioritize and reallocate the state budget to make [vaccines] available for free so that there will be no reason that people cannot get a vaccine,” the President said during a streamed briefing, noting that he had volunteered to be the first person to receive the shot to build confidence in the inoculation.
The government is hoping to secure 246.6 million vaccine doses. It has been in negotiations with Pfizer, AstraZeneca and global vaccine program COVAX, in addition to China’s Sinovac Biotech.
It has ordered about 143 million doses from Sinovac in various forms, from ready-to-administer doses to vaccine bulk, out of which individual doses of the vaccine are drawn. However, the Sinovac vaccine’s efficacy remains unknown, pending further results.
2020年 12月 18日，首尔12月18日电 韩国政府将争取在本月内与美国制药商杨森和辉瑞签署新冠疫苗采购协议，明年1月与莫德纳签署协议，还计划在明年2～3月进口日前已签约的阿斯利康疫苗。
中央灾难安全对策本部18日召开记者会公布了上述疫苗采购计划。政府此前曾表示，将通过新冠疫苗保障机制（COVAX facility）确保获得可接种1000万人的新冠疫苗，同时向海外药企预定可接种3400万人的疫苗，并在明年2～3月分阶段引进国内。
新冠疫苗保障机制方面，政府已与其签署采购协议并于10月支付850亿韩元（约合人民币5.4亿元）定金；海外药企方面，韩国已同英国阿斯利康制药公司签署购买协议，与辉瑞、强生、莫德纳三家美国公司签署预先采购协议。具体来看，将从阿斯利康、莫德纳、辉瑞各采购可接种1000万人的疫苗（各2000万剂次），从杨森引进可接种400万人的疫苗。
据悉，除上述四家药企外，政府还在与诺瓦瓦克斯医药就疫苗购买事宜进行协商。保健福祉部保健产业政策局局长林仁泽表示，政府最快能在下周与杨森完成协议签署，与辉瑞的协议也进入法律审核阶段。
林仁泽表示，政府代表团与新冠疫苗保障机制当天就采购事宜进行了谈判，具体数量和时间还有待进一步商榷。就美国总统特朗普日前签署的“美国优先获疫苗”行政令恐将影响疫苗供应的担忧，林仁泽表示这并无影响。他说，辉瑞、阿斯利康和杨森均表态称该行政命令不会影响疫苗供应，个别媒体的报道与事实不符。
马来西亚2019冠状病毒病最新数据
截至12月17日下午5时
确诊病例
确诊
89,133宗
死亡病例
432宗
仍在治疗
就医
14,671宗
出院病例
74,030宗
根据卫生部所提供的资料，每日更新各州属的最新病例。
各州属冠病病例分布
截至12月17日下午5时
州属 确诊病例 死亡病例
玻璃市 45 2
吉打 2865 (+9) 11
槟州 2863 (+80) 7
霹雳 2710 (+41) 16
雪兰莪 22931 (+368) 35
森美兰 6684 (+33) 11
马六甲 551 (+98) 5
柔佛 2835 (+67) 32 (+1)
彭亨 855 (+4) 7
登嘉楼 281 (+2) 1
吉兰丹 482 (+10) 6
沙巴 33823 (+184) 249 (+2)
砂拉越 1082 (+9) 19
吉隆坡 9426 (+297) 21
布城 222 (+2) 2
纳闽 1476 (+16) 7