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  • 29 Dec 2020. Don’t be Too Quick to Judge Sweden’s Covid-19 Policy. The Nordic country has taken an approach all its own, but it’s too soon to tell whether it’s right or wrong

    In 2008, I concluded that the next major pandemic would arrive before 2021. The very year after this forecast saw a minor event—involving the H1N1 influenza virus—but the 2019 pandemic obviously qualifies as a major global outbreak.

    This was no remarkable feat of forecasting, just a simple recognition that pandemics reappear rather frequently. A regrettable corollary is that we remain repeatedly unprepared for their spread and that we mismanage our responses on truly grand scales. But this does not prevent people from making simplistic judgments.

    Sweden’s response to the COVID-19 virus is a perfect example of this habit. The response has not been decided by politicians, it has not involved major adjustments, and all key decisions have been left to the state epidemiologist, Anders Tegnell, who has relied on appealing to his compatriots to behave responsibly.

    Even in Sweden, his approach has not remained unchallenged, but abroad it has elicited two remarkably divergent criticisms. Some say, “They did not resort to any panicky lockdowns, and they are none the worse for it,” while others say, “They did not lock down anything, and the consequences have been catastrophic.” Neither statement is true, but even an interim appraisal, made in November 2020, shows an outcome that is as singular as it is a part of a larger piece.

    To begin with, Sweden shut down high schools and universities, but not grade schools and kindergartens; it restricted very large gatherings, allowed restaurants, shops, and services to remain open, while leaving to the individual the responsibility of limiting smaller gatherings. The early consequence of these decisions seemed severe: Excess mortality began to rise steeply in late March, and in April it reached levels far higher than in any of the country’s immediate Nordic neighbors. But by midsummer, cumulative mortalities divided by the size of the population were considerably lower in Sweden than in several populous European nations. By the middle of November, cumulative death rates were twice as high in Belgium, 45 percent higher in Spain, 25 percent higher in the United States, United Kingdom, and Italy (the country with extensive restrictive lockdowns) and 12 percent higher in France. On the other hand, the mortality rate in Finland and ­Norway was only about 10 percent that of Sweden, and Denmark’s rate was about 80 percent lower.

    There is no doubt that Sweden’s numbers were inflated, in part, by the relatively high share in its population of the foreign born (who are more vulnerable to infection)—a quarter of the people are immigrants, and nearly a third have at least one parent born abroad. Similarly, comparisons of excess all-cause mortality (a rate that is better able to capture the actual death toll attributable to the pandemic) show that in October 2020 the Swedish rate was marginally lower than in France, 30 percent lower than in the United States, only half as high as in Spain—but 2.5 times higher than in Finland and five times higher than in Germany.

    EuroMOMO, which monitors mortality, shows Swedish deaths rising substantially above normal from the 13th to the 21st week of 2020, returning within normal range by the 27th week, and steadily declining afterward to below the normally expected rate by the 40th week of 2020. By the 45th week, Swedish mortality remained well below the expected level and even below the Norwegian rate.

    Meanwhile France, Italy, Spain and Belgium had, once again, high excess mortalities, and only the Finnish mortality was well below the Swedish rate. The final verdict about Sweden’s relative success or indefensible failure is still many months in coming.

    Obviously, you can use these comparisons to portray Sweden as either a success (vis-à-vis Spain, the U.K., or the United States) or a failure (vis-à-vis Germany or Finland). But we will have to wait until the second wave of the pandemic has fully asserted itself to see how such comparisons will fare.

  • 2020年12月29日 小部分新冠患者出现严重精神疾病症状

    希萨姆·古利博士治疗过几名以前从未有过精神健康问题的精神病患者,其中一名女性告诉他,她一直在想象自己的孩子被谋杀。“就好像她正在经历一部电影一样,”他说。

    希萨姆·古利(Hisam Goueli)博士几乎立刻就意识到,今年夏天来到他在长岛的精神病院的那名病人不同寻常。
    该病人是一名42岁的理疗师,是四个孩子的母亲,从未有过精神症状或任何精神疾病家族史。然而,在纽约阿米蒂维尔的南橡树医院(South Oaks Hospital)一间米色墙壁的房间里,她坐在一张桌子旁,哭着说她不断看到自己两到十岁的孩子被残忍杀害,而她自己策划了杀死他们的计划。
    “就好像她在亲历《杀死比尔》(Kill Bill)一样的电影,”古利博士说,他是一名精神科医生。
    据病人描述,她的一个孩子被卡车碾过,另一个孩子被斩首。“这是很可怕的事,明明是个出色的女性,她却说,‘我爱我的孩子,我不知道我为什么会有这种想把他们斩首的感觉,’”他说。

    关于她的病史,唯一值得注意的是,这名女性在今年春天感染了新冠病毒,她拒绝接受采访,但允许古利博士叙述她的病情。她在感染病毒后只出现了轻微的身体症状,但几个月后,她听到一个声音,先是让她自杀,然后又让她杀了自己的孩子。
    在南橡树医院,有一个针对新冠患者精神疾病的入院治疗项目,古利博士还不确定新冠病毒是否与这名女性的心理症状有关。“也许这与新冠有关,也许无关,”他回忆自己当时是这么想的。
    “但后来,”他说,“我们有了第二个、第三个和第四个病例,我们就觉得,‘出事了。’”
    确实,美国和世界各地的医生都报告了类似的病例。少数从未出现过精神健康问题的新冠患者在感染新冠病毒数周后,出现了严重的精神病症状。
    在采访和学术论文中,医生是这样描述的:
    北卡罗来纳州一名36岁的养老院员工偏执地认定她的三个孩子会被绑架,为了营救他们,她试图让他们穿过一家快餐店的免下车营业窗口。
    纽约市一名30岁的建筑工人产生了严重的妄想症,认为表亲要谋杀他,为了自我保护,他试图在床上勒死对方。
    英国一名55岁女子产生了猴子和狮子的幻觉,还认为自己的一名家人被冒名顶替了。
    除了个别报告,英国对153名新冠住院患者的神经或精神并发症所进行的一项研究发现,有10人出现了“新发精神疾病”。另一项研究在西班牙一家医院发现了10名这样的患者。在与新冠相关的社交媒体群组中,医学专业人士讨论了在美国中西部、大平原和其他地区看到的症状相似的患者。

    “我猜任何有新冠疫情的地方都可能有这种情况,”达勒姆杜克大学医学中心(Duke University Medical Center)帮助治疗那名北卡州女性的科林·史密斯(Colin Smith)博士说。他和其他医生都表示,他们的患者神经太过脆弱,不能问他们是否愿为本文接受采访,但包括那名北卡州女性在内的一些患者同意在科学论文中描述他们的病情。
    医学专家表示,他们预计这种极端精神障碍只会影响一小部分患者。但这些病例被认为是新冠的疾病过程以另一种方式影响心理健康和大脑功能的例子。
    虽然最初认为新冠病毒主要导致呼吸困难,但如今有充足证据表明,许多其他症状——包括神经、认知和心理问题——甚至都可能出现在没有严重肺部、心脏或循环系统问题的患者身上。这些症状会削弱一个人的身体功能和工作能力,通常不清楚会持续多久,也不清楚该如何治疗。
    专家们越来越相信,与大脑相关的影响可能与人体免疫系统对新冠病毒的反应有关,也可能与疾病过程导致的血管问题或炎症激增有关。
    “一些对免疫激活做出反应的神经毒素可以通过血脑屏障进入大脑,导致这种损伤,”布朗克斯区蒙特菲尔·爱因斯坦医院精神病学研究所(Psychiatry Research Institute at Montefiore Einstein)的联席主任维尔玛·加贝(Vilma Gabbay)博士说。
    加贝表示,脑部扫描、脊髓液分析和其他测试都没有发现任何脑感染,他所在的医院治疗过感染新冠后出现精神疾病的两名患者:一名49岁男性听到声音并认为自己是魔鬼,还有一名34岁女性开始携带刀具,在陌生人面前脱衣服,在食物中加入洗手液。

    报告显示,这些患者大都没有因为感染新冠而感受到身体上的极度不适。古利治疗的患者没有出现呼吸问题,但他们确实出现了轻微的神经症状,如手麻、眩晕、头痛或嗅觉减退。然后,他说,在两周到数月的时间里,他们“会发展出这种严重的精神疾病,对他们周围的人来说非常危险可怕。”
    巴尔的摩约翰斯·霍普金斯大学医学院(Johns Hopkins University School of Medicine)的神经病毒学专家罗伯特·尤肯(Robert Yolken)博士说,尽管人们的身体可能从新冠中恢复,但某些情况下,他们的免疫系统可能无法关闭,或可能因为“少量病毒被延迟清除”而继续工作。
    持续的免疫激活也是困扰许多新冠痊愈者的脑雾与记忆问题的主要解释,约翰斯·霍普金斯大学精神分裂症专家艾米丽·斯维伦斯(Emily Severance)表示,新冠痊愈后的认知和精神问题可能是由“大脑中发生的类似情况”造成的。
    尤肯表示,这可能取决于免疫反应影响了大脑的哪个区域,他补充道,“有些人有神经症状,有些人有精神症状,很多人两者皆有。”
    专家们不知道是基因构成还是未被发现的精神疾病倾向使得一些人面临更大风险。杜克大学精神急诊科医疗主任布莱恩·金凯德(Brian Kincaid)博士说,北卡罗来纳州这名女性曾对另一种病毒有过皮肤反应,这可能表明她的免疫系统对病毒感染反应活跃。
    1918年的流感病毒以及以及SARS和MERS冠状病毒等其他病毒,也曾出现零星的愈后精神病和狂躁症病例。

    “我们认为这并非新冠所独有,”阿尔伯特·爱因斯坦医学院(Albert Einstein College of Medicine)的精神病学与行为科学主席乔纳森·阿尔伯特(Jonathan Alpert)博士说,他参与撰写了关于蒙特菲奥雷医疗中心(Montefiore)患者的报告。他说,研究这些病例可能有助于增加医生对精神疾病的了解。
    精神疾病的持续时间和病人对治疗的反应各不相同。据一份病例报告显示,那位对红色产生偏执、认为护士是魔鬼,会伤害她和家人的英国女性花了40天时间康复。

  • 2020年12月30日 回顾2020年欧洲应付新冠病毒

    欧洲是最早被新冠病毒袭击的地区之一,随着2020年在一片愁云惨雾中划上句号,第二波感染又让欧洲成为大流行病的焦点。第一个大规模疫苗接种计划上路,为人们带来希望。

    第一批病例2020年一月下旬在法国获得确认,到二月中旬,意大利北部已成为大流行病的中心,三月10日,意大利全境封锁,这是自二战以来,对一个西方国家最严格的控制。

    法国和西班牙继意大利之后实施严格封锁,学校被关闭,企业关门,车站和飞机场一片死寂,欧洲的城市变得异常安静,政府花费数十亿美元来维持经济生机和人们就业。

    病毒席卷了养老院,给欧洲最脆弱的人群带来致命的打击。

    尽管感染增加,英国将封锁行动推迟两星期。

    四月五日,英国首相鲍里斯约翰逊因感染新冠病毒而住院,他在重症监护室待了几天,英国女王试图鼓舞全国士气。

    英国女王伊丽莎白二世说:“日子会好转的: 我们会和我们的朋友重聚,我们会和我们的家人重聚,我们将会重聚。”

    到初夏,感染已减少,欧洲开始开放,政府补贴公众外出消费,但这么做会有后果,随着社交聚会的增加,还有九月间学校和大学重开,感染率再次开始上升。

    联合国秘书长安东尼奥·古特雷斯说:“我们的世界抵达了一个痛苦的里程碑:新冠病毒大流行导致一百万人丧生。”

    到十月,欧洲应付第二波大流行病,事实证明,这比第一波更为致命。封锁令再度下达,几个城市出现抗议行动。

    不过,在残酷的一年结束之际,科学提供了希望。有三种疫苗的早期试验,报告的成功率高达百分之95, 英国成为第一个批准并推广大规模接种辉瑞-BioNTech疫苗的西方国家,预期欧洲也会跟进。

    诺桑比亚大学生物学家斯特吉奥斯·莫斯乔斯博士说:“这是史无前例的,它明白显示,科学界和世界各国政府有能力对抗新出现的威胁。我们必须非常仔细地考虑,还有哪些方面我们想要应用这个范例和例子,来对付威胁我们的文明的其它东西。”

  • 2020年12月28日,东南亚各国新冠肺炎疫情形势依然严峻

    2020年12月28日,泰国宣布两个月以来首次出现新冠肺炎死亡病例,同时颁布首都曼谷娱乐活动的限制措施,努力控制目前已蔓延到该国一半省市的新一波新冠肺炎疫情。

    当天,泰国新增新冠肺炎确诊病例达144例,其中,本土病例共115例,移民劳工14例,隔离区病例共15例,将该国病例总数增至6285例。新冠肺炎疫情夺走了60名泰国人的生命。

    从12月15日至27日,泰国新一波新冠肺炎疫情蔓延到该国77个省市中的43个。泰国官员立即将龙仔厝体育场变成一个可容纳540张病床的野战医院。

    当天,印度尼西亚外交部长蕾特诺·马尔苏迪(Retno Marsudi)表示,从2021年1月1日起,该国将禁止外国游客入境,实施时间为两周。据报道,蕾特诺表示,此举是为了防止变异新冠病毒在印尼传播。蕾特诺同时指出,新规将适用于所有外国游客,不过不包含外国政府高级官员。

    之前,印尼12月24日禁止来自英国游客入境,加紧对来自欧洲和澳大利亚游客的入境规定,避免变异新冠病毒扩散蔓延。

    马来西亚国家安全委员会(NSC)12月28日决定将雪兰莪、吉隆坡和沙巴的有条件行管令延长14天,到2021年1月14日为止。

    越通社驻马来西亚记者报道,马来西亚国防部高级部长伊斯梅尔沙比里表示,由于上述三州的新冠肺炎确诊病例高居不下,因此国安会决定延迟条管令。从12月14日至27日,雪兰莪和吉隆坡新冠肺炎确诊病例超4.3万例。

    12月28日,马来西亚新增病例达1594例和治愈病例达1181例。然而,该国检测结果仍呈现阳性的病例特高,共20233例。

  • 29 Dec, 2020 . Spain to keep list of people who refuse Covid-19 vaccination & share data with ‘European partners’— health minister

    Spain’s health minister said authorities will keep a list of people who decline to get vaccinated and share it with other European countries. The data will be protected and not publicly available, he said.
    “We will have a registry… of people who have been offered [the vaccine] and have simply rejected it,” Salvador Illa told La Sexta TV channel, adding that the list will be shared with “European partners.”

    It is not a document that will be made public and it will be done with the utmost respect for data protection.

    Illa explained that the list would help to avoid confusion over why some people had not been vaccinated.

    Spain officially launched its immunization campaign on Sunday using the Pfizer-BioNTech vaccine.

    Illa said the shots will be administered in accordance with “priorities” laid out by the country’s vaccination plan. “Citizens will be summoned when their turn comes, and what we are asking is – when you are summoned, go to the appointment,” the minister stated, stressing that getting a shot is strictly “voluntary, not mandatory.”

    The EFE news agency reported on Tuesday that more than 350,000 doses of the vaccine were delivered to the nation’s major cities, from where they will be distributed across the country.

    Mass vaccinations began across the EU over the weekend, shortly after the bloc’s drug regulator approved the Pfizer vaccine and weeks after nationwide vaccinations started in the UK.

    “First we protect the more vulnerable. Soon we’ll have enough doses for all of us,” European Commission chief Ursula von der Leyen said on Sunday.